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The measurement by the D0 collaboration of a large like-sign dimuon asymmetry deviates significantly from Standard Model expectations. New Physics may be invoked to account for such a deviation. We analyse how generic extensions of the Standard Model where the Cabibbo-Kobayashi-Maskawa mixing matrix is enlarged can accommodate a significant enhancement of with respect to standard expectations through enhancements of the individual semileptonic asymmetries and in the - and - systems. The potential enhancement reachable in this class of scenario is, nevertheless, insufficient to reproduce the D0 measurement.

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