I investigate the behavior of spin-dependent parton distribution functions in the regions of small and large momentum fractions . I present a systematic comparison between predictions for relevant observables obtained with various models of nucleon spin structure and a recent global analysis of spin-dependent distributions, NNPDFpol1.1. Together with its unpolarized counterpart, NNPDF2.3, they form a mutually consistent set of parton distributions. Because they include most of the available experimental information, and are determined with a minimally biased methodology, these are especially suited for such a study. I show how NNPDFpol1.1 can discriminate between different theoretical models, even though NNPDF uncertainties remain large near the endpoints $x\to 0x\to 1$, due to the lack of experimental information. I discuss how our knowledge of nucleon spin structure may be improved at small- by future measurements at an Electron-Ion Collider, and at large- by recent measurements at Jefferson Lab, also in view of its GeV upgrade.

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