In this article, we establish a nearly sharp localized weighted inequality related to Gagliardo and Sobolev seminorms, respectively, with the sharp -weight constant or with the specific -weight constant when . As applications, we further obtain a new characterization of Muckenhoupt weights and, in the framework of ball Banach function spaces, an inequality related to Gagliardo and Sobolev seminorms on cubes, a Gagliardo–Nirenberg interpolation inequality, and a Bourgain–Brezis–Mironescu formula. All these obtained results have wide generality and are proved to be (nearly) sharp. The original version of this article was published in [Adv. Math. 481 (2025), Paper No. 110537]. In this revised version, we correct an error appeared in Theorem 1.1 in the case where , which was pointed out to us by Emiel Lorist.

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