We introduce and study a new class of pseudo-differential operators associated with a fractional Hankel–Bessel transform. Motivated by the classical Hankel transform and the pseudo-differential operators associated with Bessel operators studied by Pathak and Pandey \cite{PathakPandey1995}, we define a fractional variant by inserting a fractional Fourier-type phase into the Hankel kernel. We then introduce global Shubin-type symbol classes adapted to this transform, derive kernel estimates and integral representations, and establish boundedness results on weighted L^{p}-spaces and on fractional Hankel–Sobolev spaces. This provides a new framework parallel to the classical Hankel pseudo-differential calculus, but in a fractional and global setting.

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