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In this paper, we consider the local well-posedness of the Prandtl boundary layer equations that describe the behavior of boundary layer in the small viscosity limit of the compressible isentropic Navier-Stokes equations with non-slip boundary condition. Under the strictly monotonic assumption on the tangential velocity in the normal variable, we apply the Nash-Moser-H"{o}rmander iteration scheme and further develop the energy method introduced in [1] to obtain the well-posedness of the equations locally in time.

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