The coherent mobility of doublons, arising from second-order virtual dissociation-recombination processes, fundamentally limits their use as information carriers in the strongly interacting Bose-Hubbard model. We propose a disorder-free suppression mechanism by introducing an optimized nearest-neighbor pair-hopping term that destructively interferes with the dominant virtual hopping channel. Using the third-order Schrieffer-Wolff transformation, we derive an analytical optimal condition that accounts for lattice geometry corrections. Exact numerical simulations demonstrate that this optimized scheme achieves near-complete dynamical arrest and entanglement preservation in one-dimensional chains, while in two-dimensional square lattices, it significantly suppresses ballistic spreading yet permits a slow residual expansion. Furthermore, in the many-body regime, finite-size scaling analysis identifies the observed long-lived density-wave order as a prethermal plateau emerging from the dramatic separation of microscopic and thermalization timescales.

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