Let be a reductive spherical pair and a parabolic subgroup such that is spherical. The triples with this property are called multiplicity free systems and they are classified in this paper. Denote by the Borel-Weil realization of the irreducible -representation of highest weight $\mu\in P^{+}{H}{P}^{G}\chi_{\mu}={H}^{G}\pi^{H}{\mu}$, a multiplicity free induced representation. Some properties of the spectrum of the multiplicity free induced representations are discussed. For three multiplicity free systems the spectra are calculated explicitly. The spectra give rise to families of multi-variable orthogonal polynomials which generalize families of Jacobi polynomials: they are simultaneous eigenfunctions of a commutative algebra of differential operators, they satisfy recurrence relations and they are orthogonal with respect to integrating against a matrix weight on a compact subset. We discuss some difficulties in describing the theory for these families of polynomials in the generality of the classification.

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