We consider the global Cauchy problem for the generalized incompressible Navier- Stokes system in 3D whole space \begin{equation}\label{main0} \nabla\cdot u=0, \end{equation} where and are the fluid velocity field and pressure. The initial data is assumed to be smooth, rapidly decreasing and divergence free. Here is the anisotropic hyperdissipative operator. When , it is called the critical case and the global smooth solution exists. We consider the anisotropic operator with $hu= \left(\begin{array}{c} \partial{x_1x_1} u_1+\partial_{x_2x_2} u_1- M_3^{2\alpha} u_1 \partial_{x_1x_1} u_2+\partial_{x_2x_2} u_2-M_3^{2\alpha} u_2 \ - M_1^{2\gamma} u_3-M_2^{2\gamma} u_3-M_3^{2\alpha} u_3 \end{array} \right). $ and establish global regularity.

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