We study general (not necessarily Hamiltonian) first-order symmetric systems on an interval with the regular endpoint . It is assumed that the deficiency indices of the minimal relation satisfy . We define -depending boundary conditions which are analogs of separated self-adjoint boundary conditions for Hamiltonian systems. With a boundary value problem involving such conditions we associate an exit space self-adjoint extension of and the -function , which is an analog of the Titchmarsh-Weyl coefficient for the Hamiltonian system. By using -function we obtain the eigenfunction expansion with the spectral function of the minimally possible dimension and characterize the case when spectrum of is defined by . Moreover, we parametrize all spectral functions in terms of a Nevanlinna type boundary parameter. Application of these results to ordinary differential operators of an odd order enables us to complete the results by Everitt and Krishna Kumar on the Titchmarsh-Weyl theory of such operators.

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