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Matter-induced neutrino flavor mixing (the Mikheyev-Smirnov-Wolfenstein, or MSW, effect) is a central prediction of the neutrino mixing framework, but it has not been conclusively observed. Direct observation of the energy-dependent MSW transition in the solar electron-neutrino survival probability would solve this, but backgrounds have been prohibitive. We show that our new technique for suppressing muon-induced spallation backgrounds will allow JUNO to measure the MSW transition at 4 significance in 10 years. This would strongly support upcoming multi-$1B next-generation long-baseline experiments and their goals in cementing the neutrino mixing framework.

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