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In this work, we introduce a sample- and data-based moving horizon estimation framework for linear systems. We perform state estimation in a sample-based fashion in the sense that we assume to have only few, irregular output measurements available. This setting is encountered in applications where measuring is expensive or time-consuming. Furthermore, the state estimation framework does not rely on a standard mathematical model, but on an implicit system representation based on measured data. We prove sample-based practical robust exponential stability of the proposed estimator under mild assumptions. Furthermore, we apply the proposed scheme to estimate the states of a gastrointestinal tract absorption system.

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