We derive the gravitational radiation-reaction (RR) force in the harmonic coordinate system at the fourth-and-a-half post-Newtonian (4.5PN) order in the case of compact binary systems. Dimensional regularization is used to treat the ultra-violet divergences which appear at that order. We prove that the RR acceleration implies the known radiation fluxes at infinity associated with energy, angular momentum, linear momentum, and center-of-mass position. As a consistency check, we verify the manifest Lorentz invariance of the RR acceleration in harmonic coordinates. Our result should be useful for comparisons with other approaches such as the gravitational self force (GSF) and the post-Minkowskian (PM) effective field theory.

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