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We update the flavor-violating constraints on the charged Higgs sector of the 2-Higgs Doublet Model Type-III (2HDM-III), using a four-zero texture in the Yukawa matrices. We give a generic Lagrangian of the 2HDM-III. In order to show the relevance of the off-diagonal terms of such a texture, we utilize the main constraints from -physics, universality in decays and the radiative decay presented recently in arXiv:1212.6818 [hep-ph]. In particular, we show that the coupling can be very large and very different with respect to 2HDMs with a flavor discrete symmetry (i.e., ). We also discuss the possible enhancements of the vertices () that arise at one-loop level.

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