Given solenoidal vector $\r_0-1\in L^2(\R^2),\r_0 \in L^\infty\cap\dot{W}^{1,r}(\R^2)$ with a positive lower bound for and we prove that 2-D incompressible inhomogeneous Navier-Stokes system \eqref{1.1} has a unique global solution provided that the viscous coefficient \mu(\r_0) is close enough to 1 in the norm compared to the size of and the norms of the initial data. With smoother initial data, we can prove the propagation of regularities for such solutions. Furthermore, for if (\r_0-1,u_0) belongs to the critical Besov spaces $\dB^{\f2p}{p,1}(\R^2)\times \bigl(\dB^{-1+\f2p}{p,1}\cap L^2(\R^2)\bigr)\dB^{\f2p}{p,1}(\R^2)\r_0-1|u_0|{L^2}^2+|u_0|{\dB^{-1+\f2p}{p,1}},$ we prove the global well-posedness of \eqref{1.1} in the scaling invariant spaces. Finally for initial data in the almost critical Besov spaces, we prove the global well-posedness of \eqref{1.1} under the assumption that the norm of \r_0-1 is sufficiently small.

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