We use equivariant localization and divided difference operators to determine formulas for the torus-equivariant fundamental cohomology classes of -orbit closures on the flag variety for various symmetric pairs . In type , we realize the closures of -orbits on as universal degeneracy loci for a vector bundle over a variety which is equipped with a single flag of subbundles and which splits as a direct sum of subbundles of ranks and . The precise description of such a degeneracy locus relies upon knowing a set-theoretic description of -orbit closures, which we provide via a detailed combinatorial analysis of the poset of “-clans,” which parametrize the orbit closures. We describe precisely how our formulas for the equivariant classes of -orbit closures can be interpreted as formulas for the classes of such degeneracy loci in the Chern classes of the bundles involved. In the cases outside of type , we suggest that the orbit closures should parametrize degeneracy loci involving a vector bundle equipped with a non-degenerate symmetric or skew-symmetric bilinear form, a single flag of subbundles which are isotropic or Lagrangian with respect to the form, and a splitting as a direct sum of subbundles with each summand satisfying some property (depending on ) with respect to the form. The precise description of such a degeneracy locus is conjectured for all cases in types and .

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