We introduce a new variational method for the numerical homogenization of divergence form elliptic, parabolic and hyperbolic equations with arbitrary rough () coefficients. Our method does not rely on concepts of ergodicity or scale-separation but on compactness properties of the solution space and a new variational approach to homogenization. The approximation space is generated by an interpolation basis (over scattered points forming a mesh of resolution ) minimizing the norm of the source terms; its (pre-)computation involves minimizing quadratic (cell) problems on (super-)localized sub-domains of size . The resulting localized linear systems remain sparse and banded. The resulting interpolation basis functions are biharmonic for , and polyharmonic for , for the operator and can be seen as a generalization of polyharmonic splines to differential operators with arbitrary rough coefficients. The accuracy of the method ( in energy norm and independent from aspect ratios of the mesh formed by the scattered points) is established via the introduction of a new class of higher-order Poincar'{e} inequalities. The method bypasses (pre-)computations on the full domain and naturally generalizes to time dependent problems, it also provides a natural solution to the inverse problem of recovering the solution of a divergence form elliptic equation from a finite number of point measurements.

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