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In the present paper we study the impact of dispersion and nonlinearity on DNA dynamics. We rely on the helicoidal Peyrard-Bishop model and use the fact that nonlinear DNA dynamics represents an interplay between nonlinearity and dispersion. We state that a dispersion coefficient and a coefficient of nonlinearity, existing in nonlinear Schr"odinger equation, are mutually dependent and show how function and can be obtained. Also, we show how all this can be used to find a possible interval for the parameter describing helicoidal structure of DNA.

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