The parity-time-reversal- () symmetric quantum mechanics (PTQM) has developed into a noteworthy area of research. However, to date most known studies of PTQM focused on the spectral properties of non-Hermitian Hamiltonian operators. In this work, we propose an axiom in PTQM in order to study general time-dependent problems in PTQM, e.g., those with a time-dependent -symmetric Hamiltonian and with a time-dependent metric. We illuminate our proposal by examining a proper mapping from a time-dependent Schr"odinger-like equation of motion for PTQM to the familiar time-dependent Schr"odinger equation in conventional quantum mechanics. The rich structure of the proper mapping hints that time-dependent PTQM can be a fruitful extension of conventional quantum mechanics. Under our proposed framework, we further study in detail the Berry phase generation in a class of -symmetric two-level systems. It is found that a closed path in the parameter space of PTQM is often associated with an open path in a properly mapped problem in conventional quantum mechanics. In one interesting case we further interpret the Berry phase as the flux of a continuously tunable fictitious magnetic monopole, thus highlighting the difference between PTQM and conventional quantum mechanics despite the existence of a proper mapping between them.

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