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In this paper, we consider the short time classical solution to a simplified hydrodynamic flow modeling incompressible, nematic liquid crystal materials in dimension three. We establish a criterion for possible breakdown of such solutions at a finite time. More precisely, if is smooth up to time provided that $\int_0^T|\nabla\times u(t,\cdot)|{BMO(\mathbb R^3)}+|\nabla d(t,\cdot)|^8{L^4(\mathbb R^3)}dt<\infty $

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