An exploratory study of chiral four-nucleon interactions in nuclear and neutron matter is performed. The leading-order terms arising from pion-exchange in combination with the chiral -vertex and the chiral NN-vertex are found to be very small. Their attractive contribution to the energy per particle stays below MeV in magnitude for densities up to $\rho =0.4,^{-3}$. We consider also the four-nucleon interaction induced by pion-exchange and twofold -isobar excitation of nucleons. For most of the closed four-loop diagrams the occurring integrals over four Fermi spheres can either be solved analytically or reduced to easily manageable one- or two-parameter integrals. After summing the individually large contributions from 3-ring, 2-ring and 1-ring diagrams of alternating signs, one obtains at nuclear matter saturation density fm a moderate contribution of MeV to the energy per particle. The curve $\bar E(\rho)\rho$. In pure neutron matter the analogous chiral four-body interactions lead, at the same density , to a repulsive contribution that is about half as strong. The present calculation indicates that long-range multi-nucleon forces, in particular those provided by the strongly coupled $\pi N \Delta293,$MeV, can still play an appreciable role for the equation of state of nuclear and neutron matter.

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