In this paper, we prove the global well-posedness of the classical solution to the 2D Cauchy problem of the compressible Navier-Stokes equations with arbitrarily large initial data when the shear viscosity is a positive constant and the bulk viscosity \l(\r)=\r^\b with . Here the initial density keeps a non-vacuum states at far fields and our results generalize the ones by Vaigant-Kazhikhov [41] for the periodic problem and by Jiu-Wang-Xin [26] and Huang-Li [8] for the Cauchy problem with vacuum states at far fields. It shows that the solution will not develop the vacuum states in any finite time provided the initial density is uniformly away from vacuum. And the results also hold true when the initial data contains vacuum states in a subset of and the natural compatibility conditions are satisfied. Some new weighted estimates are obtained to establish the upper bound of the density.

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