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We present a determination of the nucleon parton distribution functions (PDFs) and of the strong coupling constant at next-to-next-to-leading order (NNLO) in QCD based on the world data for deep-inelastic scattering and the fixed-target data for the Drell-Yan process. The analysis is performed in the fixed-flavor number scheme for and uses the scheme for and the heavy quark masses. The fit results are compared with other PDFs and used to compute the benchmark cross sections at hadron colliders to the NNLO accuracy.

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