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We study the Cauchy problem for the Gross-Pitaevskii equation with a nonlocal interaction potential of Hartree type in three space dimensions. If the potential is even and positive definite or a positive function and its Fourier transform decays sufficiently rapidly the problem is shown to be globally well-posed for large rough data which not necessarily have finite energy and also in a situation where the energy functional is not positive definite. The proof uses a suitable modification of the I-method.

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