We construct a radiative inverse seesaw model with local B-L symmetry, and investigate the flavor structure of the lepton sector and the fermionic Dark Matter. Neutrino masses are radiatively generated through a kind of inverse seesaw framework. The PMNS matrix is derived from each mixing matrix of the neutrino and charged lepton sector with large Dirac CP phase. We show that the annihilation processes via the interactions with Higgses which are independent on the lepton flavor violation, have to be dominant in order to satisfy the observed relic abundance by WMAP. The new interactions with Higgses allow us to be consistent with the direct detection result reported by XENON100, and it is possible to verify the model by the exposure of XENON100 (2012).

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