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Motivated by the deviation from no CP violation hypothesis for the CP asymmetry (CPA) difference between and $D^0\to \pi^+ \pi^-$, reported recently by LHCb and CDF, we investigate the CP violating effect due to the left-right (LR) mixing in the general LR symmetric model. In particular, in the non-manifest LR model we show that the large CPA difference could be explained, while the constraints from and - are satisfied.

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