We compute next-to-next-to-leading order corrections to the decay width difference of mass eigenstates and the charge-parity (CP) asymmetry in flavour-specific decays of neutral mesons. We include both current-current and penguin operators at three-loop order. All input integrals in the transition amplitude are reduced to a small set of master integrals which depend on the ratio of the charm and bottom quark masses. The latter are computed using semi-analytic methods which provide deep expansions around properly selected values of . We provide numerical results for and , both for the and system, including a detailed uncertainty analysis. Using the experimental value for the mass difference we predict . For the CP asymmetries we find and . Furthermore, we show that the ratios and can be predicted with high precision. The former quantity permits the prediction from the measurements of and . We further discuss the impact of on the CKM unitarity triangle and present ready-to-use formulae which permit improved predictions once updated results for the operator matrix elements are available.

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