The renormalization scale uncertainty can be eliminated by the Principle of Maximum Conformality (PMC) in a systematic scheme-independent way. Applying the PMC for the -pair hadroproduction at the NNLO level, we have found that the total cross-sections at both the Tevatron and LHC remain almost unchanged when taking very disparate initial scales $\mu^{\rm init}Rm_t10,m_t20,m_t\sqrt{s}$, which is consistent with renormalization group invariance. As an important new application, we apply PMC scale-setting to study the top-quark forward-backward asymmetry. We observe that the more convergent perturbative series after PMC scale-setting leads to a more accurate top-quark forward-backward asymmetry. The resulting PMC prediction on the asymmetry is also free from the initial renormalization scale-dependence. Because the NLO PMC scale has a dip behavior for the -channel at small subprocess collision energies, the importance of this channel to the asymmetry is increased. We observe that the asymmetries and at the Tevatron will be increased by 42% in comparison to the previous estimates obtained by using conventional scale-setting; i.e. we obtain $A{FB}^{t\bar{t},{\rm PMC}} \simeq 12.5%A_{FB}^{p\bar{p},{\rm PMC}} \simeq 8.28%A_{FB}^{t\bar{t},{\rm PMC}}(M_{t\bar{t}}>450 ;{\rm GeV}) \simeq 35.0%$. These predictions have a -deviation from the present CDF and D0 measurements; the large discrepancies of the top-quark forward-backward asymmetry between the Standard Model estimate and the CDF and D0 data are thus greatly reduced.

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