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Despite quantum tunneling has been studied since the advent of quantum mechanics, the literature appears to contain no simple (textbook) formula for tunneling in generic asymmetric double-well potentials. In the regime of strong localization, we derive an succinct analytical formula based on the WKB semi-classical approach. Two different examples of asymmetric potentials are discussed: when the two localized levels are degenerate or not. For the first case, we also discuss a time-dependent problem showing quantum Zeno effect.

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