Let be a von Neumann algebra equipped with a faithful normal semi-finite trace and let be the algebra of all -compact operators affiliated with . Let $E(\tau)\subseteq S_0(\tau)\tau$-compact operators in . We study (i) derivations on with the range in and (ii) derivations on the Banach algebra . In the first case our main results assert that such derivations are continuous (with respect to the norm topologies) and also inner (under some mild assumptions on ). In the second case we show that any such derivation is necessarily inner when is a type factor. As an interesting application of our results for the case (i) we deduce that any derivation from into an -space, , () associated with is inner.

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