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We describe noncommutative desingularizations of determinantal varieties, determinantal varieties defined by minors of generic symmetric matrices, and pfaffian varieties defined by pfaffians of generic anti-symmetric matrices. For maximal minors of square matrices and symmetric matrices, this gives a non-commutative crepant resolution. Along the way, we describe a method to calculate the quiver with relations for any non-commutative desingularizations coming from exceptional collections over partial flag varieties.

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