We consider the spatially homogeneous Landau equation for multiple species with different masses. As in the single-species case, the singularity of the collision operator is determined by a parameter , where corresponds to Coulomb interactions. We prove that if in the cross-interaction operators, then there exists a natural multi-species generalization of the Fisher information which is a Lyapunov functional for the multi-species Landau system. On the other hand, we give a counterexample showing that the Fisher information is in general no longer a Lyapunov functional below the threshold for the two-species system if one species has infinite mass. However, we are able to provide a new method to show global well-posedness, by constructing a different Lyapunov functional based on the spherical Fisher information.

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