We systematically study the spectrum of excitations and the one-loop determinant of holographic Wilson loop operators in antisymmetric representations of supersymmetric Yang-Mills theory. Holographically, these operators are described by D5-branes carrying electric flux and wrapping an in the bulk background. We derive the dynamics of both bosonic and fermionic excitations for such D5-branes. A particularly important configuration in this class is the D5-brane with worldvolume and units of electric flux, which is dual to the circular Wilson loop in the totally antisymmetric representation of rank . For this Wilson loop, we obtain the spectrum, show explicitly that it is supersymmetric and calculate the one-loop effective action using heat kernel techniques.

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