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Charm and beauty production are probed with the ALICE experiment at the LHC by studying the single lepton transverse momentum distribution (electrons at mid-rapidity, muons at large-rapidities) and D mesons reconstructed in their hadronic decays. The differential production cross sections in proton proton interactions show a good agreement with perturbative QCD calculations at both sqrt(s) = 2.76 and 7 TeV. The measurements in lead lead reactions at sqrt(s_{NN})= 2.76 TeV evidence a reduction (or suppression) of the production rate at intermediate and high pt in the most central collisions with respect to the rate in proton proton interactions.

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