Heavy-flavor production in pp and Pb-Pb collisions at LHC with ALICE

We report recent results from the ALICE experiment the Large Hadron Collider on open charmed hadron production in pp collisions at $\sqrt{s}=2.76$ and 7 TeV, and Pb-Pb collisions at $\sqrt{{\mathrm{s}}_{{}_{\mathrm{N}\mathrm{N}}}}=2.76$ TeV. Open charmed hadrons are kinematically fully reconstructed in the hadronic decay channels \DtoKpi, \DtoKpipi, and \DstartoDpi %$D^0\to K^{-}{\pi }^{+}$, $D^{+}\to K^{-}{\pi }^{+}{\pi }^{+}$, and $D^{*+} \rightarrow D^0 (K^-\pi^+) + \pi^+$ and identified through their invariant mass. Combinatorial background is minimized by selecting a displaced vertex topology. Inclusive charm and beauty production is measured by detecting electrons (muons) from semi-leptonic decays of open charmed and beauty hadrons in the central (forward) region. Comparison to results from state-of-the-art QCD calculations is given. First results on nuclear modifications factors in Pb–Pb collisions from hadronic and semi-leptonic decays are presented.