Let be a hypersurface with isolated singularities defined by in with . The difference is called the defect of (for self-duality of the cohomology of ). It is known that its vanishing is closely related to -factoriality of in the rational singularity case with . This number coincides with the dimension of the cokernel of the inclusion , the rank of the morphism from the vanishing cohomologies of to for a one-parameter smoothing of with total space smooth, and also with the dimension of the unipotent monodromy part of the Milnor fiber cohomology of with degree . In the case has only weighted homogeneous isolated singularities, the defect is then given by the -term of the spectral sequence of the double complex with differentials and by the -degeneration of the pole order spectral sequence. It can be calculated explicitly using a computer even for analogues of the Hirzebruch quintic threefold with more than one hundred ordinary double points found by B.\ van Geemen and J.\ Werner in a compatible way with their computation. We give also an example with and where .

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