nonlinearities and spatial weights of Hénon type. Motivated by the symmetry-breaking phenomena observed in semilinear second-order problems – such as those governed by the Hénon equation – we consider weighted functionals of the form \begin{equation*} F_m(u) = \int_B |x|^α\left( e^{σ|u|^2} - \sum_{k=0}^m \frac{σ^k}{k!} |u|^{2k} \right) dx, \end{equation*} defined on the unit ball , where , are suitable parameters. We first establish an Adams-type inequality with weight, characterizing the sharp threshold for the boundedness of on the unit sphere of the biharmonic Sobolev space. Then, we prove that for large values of the weight exponent , radial symmetry of maximizers is broken. %, i.e., the supremum of the functional is strictly larger when taken over the full space compared to the radial subspace. These results extend classical findings in the second-order setting (e.g., Trudinger–Moser-type functionals and the weighted Hénon equation) to the biharmonic context and offer new insights into the interplay between weights, nonlinearity, and symmetry in higher-order PDEs.

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