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We characterise smooth curves in P^3 whose blow-up produces a threefold with anticanonical divisor big and nef. These are curves C of degree d and genus g lying on a smooth quartic, such that (i) or $(g,d) = (19,12)$, (ii) there is no 5-secant line, 9-secant conic, nor 13-secant twisted cubic to C. This generalises the classical similar situation for the blow-up of points in P^2. We describe then Sarkisov links constructed from these blow-ups, and are able to prove the existence of Sarkisov links which were previously only known as numerical possibilities.

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