Within the perturbative QCD approach and ignoring the contributions of long distance and subleading penguin loops, we investigate $\bar B^0 \to D^0 \mu^+\mu^-$ decay in the large recoiling kinematic region in the Standard Model. At the tree level, decays to by exchanging a boson accompanied by a virtual photon emission from the valence quarks of and meson, then the virtual photon decays to the lepton pair. Numerically, we find that the branching ratio decreases rapidly as the increases, and the branching ratio of is in the region $q^2 \in [1,5] ^2$. The order of the branching ratio shows a possibility to study this interesting channel in the current factories and the Large Hadron Collider. The precise experimental data will help us to test the factorization approach and the QCD theory, in general.

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