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Diffraction phenomena of large molecules have been studied in many experiments, and these experiments are described by many theoretical works. In this paper, we study molecules single and double-slit diffraction with quantum theory approach, and we pay close attention to the diffraction experiment carried out by A.Zeilinger et.at in 1999. In double-slit diffraction, we consider the decoherence effect, and find the theoretical results are good agreement with experimental data.

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