In this paper we complete the determination of the index of factoriality of moduli spaces of semistable sheaves on an abelian or projective K3 surface . If is a Mukai vector, is primitive, and is a generic polarization, let be the moduli space of semistable sheaves on with Mukai vector . First, we describe in terms of the pure weight-two Hodge structure and the Beauville form on the second integral cohomology of the symplectic resolutions of (when is K3) and of the fiber of the Albanese map of (when is abelian). Then, if is K3 we show that is either locally factorial or factorial, and we give an example of both cases. If is abelian, we show that and are factorial.

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