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We consider non-local elliptic operators with kernel , where is a constant and is a bounded measurable function. By using a purely analytic method, we prove the continuity of the non-local operator from the Bessel potential space to , and the unique strong solvability of the corresponding non-local elliptic equations in spaces. As a byproduct, we also obtain interior -estimates. The novelty of our results is that the function is not necessarily to be homogeneous, regular, or symmetric. An application of our result is the uniqueness for the martingale problem associated to the operator .

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