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We present the first lattice calculation of nucleon matrix elements using four dynamical flavors. We use the maximally twisted mass formulation. The renormalization is performed non-perturbatively in the RI-MOM scheme and results are given for the vector and axial vector operators with up to one-derivative. Our calculation of the average momentum of the unpolarized non-singlet parton distribution is presented and compared to our previous results obtained from the case.

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