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Heavy-quark interactions in the Quark-Gluon Plasma are analyzed in terms of a selfconsistent Brueckner scheme using a thermodynamic -matrix based on a potential model. The interrelations between quarkonium correlators, spectral functions and zero-modes, and open heavy-flavor transport and susceptibilities are elaborated. Independent constraints from thermal lattice QCD can be used to improve predictions for heavy-quark phenomenology in heavy-ion collisions.

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