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This manuscript is the written form of three lectures delivered by David Chandler at the International School of Physics “Enrico Fermi”, Course CLXXVI - “Complex materials in physics and biology”, in Varenna, Italy in July 2010. It describes the physical properties of water from a molecular perspective and how these properties are reflected in the behaviors of water as a solvent. Theory of hydrophobicity and solvation of ions are topics included in the discussion.

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