Collective response of self-organised clusters of mechanosensitive channels

Mechanosensitive channels are ion channels activated by membrane tension. We investigate the influence of bacterial mechanosensitive channels spatial distribution on activation (gating). Based on elastic short-range interactions we map this physical process onto an Ising-like model, which enables us to predict the clustering of channels and the effects of clustering on their gating. We conclude that the aggregation of channels and the consequent interactions among them leads to a global cooperative gating behaviour with potentially dramatic consequences for the cell.