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We study cascade hierarchy in supersymmetric SU(5) grand unified theory. The neutrino Dirac mass matrix of the cascade form can lead to the tri-bimaximal generation mixing at the leading order in the seesaw mechanism while the down quark mass matrix of a hybrid cascade form naturally gives the CKM structure. We embed such experimentally favored mass textures into supersymmetric SU(5) GUT, which gives a relation between the down quark and charged lepton mass matrices. Related phenomenologies, such as lepton flavor violating processes and leptogenesis, are also investigated in addition to lepton mixing angles.

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