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In this paper we establish the existence and uniqueness of solutions for nonlinear evolution equations on Banach space with locally monotone operators, which is a generalization of the classical result by J.L. Lions for monotone operators. In particular, we show that local monotonicity implies the pseudo-monotonicity. The main result is applied to various types of PDE such as reaction-diffusion equations, generalized Burgers equation, Navier-Stokes equation, 3D Leray- model and -Laplace equation with non-monotone perturbations.

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