A time inhomogeneous generalized Mehler semigroup on a real separable Hilbert space is defined through for every bounded measurable function on , where is an evolution family of bounded operators on and is a family of probability measures on $({\mathds{H}}, \B({\mathds{H}}))$ This kind of semigroup is closely related with the transition semigroup" of non-autonomous (possibly non-continuous) Ornstein-Uhlenbeck process driven by some proper additive process. We show the weak continuity, infinite divisibility, associated “additive processes”, L'evy-Khintchine type representation, construction and spectral representation of $(\mu_{t,s})_{t\geq s}$. We study the structure, existence and uniqueness of the corresponding evolution systems of measures (=space-time invariant measures) of . We also establish dimension free Harnack inequalities in the sense of Wang (1997, PTRF) for . As applications of the Harnack inequalities, we investigate the strong Feller property and contractivity etc. for . Finally we prove a Harnack inequality and show the strong Feller property for the transition semigroup of a semi-linear non-autonomous Ornstein-Uhlenbeck process driven by a Wiener process.

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