Based on the Hugenholtz-Van Hove theorem, it is shown that both the symmetry energy E and its density slope at normal density are completely determined by the global nucleon optical potentials that can be extracted directly from nucleon-nucleus scatterings, (p,n) charge exchange reactions and single-particle energy levels of bound states. Adopting a value of for the nucleon effective k-mass in symmetric nuclear matter at and averaging all phenomenological isovector nucleon potentials constrained by world data available in the literature since 1969, the best estimates of MeV and MeV are simultaneously obtained. Uncertainties involved in the estimates are discussed.

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