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We have studied the novel isotope effects on the pairing pseudogap in underdoped and optimally doped cuprates within the large-polaron model and two non-standard BCS-like approaches. We have shown that in the intermediate-coupling regime the precursor pairing of large polarons occurs at a mean-field temperature and the near-absent, sizable and very large oxygen and copper isotope effects on exist in cuprates with small and large Fermi surfaces. Our results for , isotope shifts and exponents in slightly underdoped and optimally doped cuprates are in quantitative agreement with existing experiments and explain the discrepancy between various experiments.

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